Engineering

Amgen

Process Development Associate- Attribute Sciences

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Process Development Associate- Attribute Sciences**

**What you will do**

Lets do this. Lets change the world. Amgen is a leading biotechnology company with a mission to serve patients around the world. As a science-based, patient-focused organization, we discover and develop innovative therapies to treat serious illnesses.

Amgens Attribute Sciences (AS) department within the Process Development (PD) organization defines the favorable quality characteristics of the therapies it produces and optimizes innovative analytical tools to guide that development. The Pivotal PD organizations focus is developing and commercializing robust manufacturing processes across a wide range of therapeutic biologic modalities, including (but not limited to) monoclonal and bispecific antibodies, bispecific T-cell engagers (BiTEs), live oncolytic viruses, and synthetic medicines.

As a PD Associate, the candidate will participate in protein characterization studies to support regulatory filings using High Performance Liquid Chromatography (HPLC) / Ultra Performance Liquid Chromatography (UPLC) and mass spectrometry (MS). The candidate will also work to develop, qualify, and transfer analytical methods to Quality Control, and optimize and troubleshoot existing methods.

They will collaborate with other process development departments to support commercial process development and process characterization studies in support of marketing applications.

This position is located at our Thousand Oaks, CA site.

**Key responsibilities:**

Perform method development and qualification studies using HPLC, UPLC, and Capillary Electrophoresis platforms

Perform chromatographic fractionation, peptide mapping, intact mass, and other LC-MS studies to support product characterization and comparability studies

Author results in laboratory notebooks and method development reports, interfacing closely with Attribute Sciences Team Leads and Quality Control to transfer and troubleshoot qualified methods

Participate in the maintenance of Attribute Sciences instruments and assist the Attribute Sciences department in maintaining a phase appropriate good manufacturing practices (GMP) environment

With a focus toward evaluation of critical quality attributes, coordinate and perform attribute identification and characterization studies, including isolation and analysis of chromatography fractions

Conduct and coordinate accelerated stability studies to define therapeutic degradative pathways

Perform evaluation of novel platform analytical technologies to help drive innovation

Perform experiments to help answer questions from health authorities

Collaborate with partner organizations during commercial process development, process characterization, and process validation studies to support marketing applications

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications.

**Basic Qualifications:**

Bachelors degree

OR

Associates degree and 2 years of Scientific experience

OR

High school diploma / GED and 4 years of Scientific experience

**Preferred Qualifications:**

- Scientific background in method development and product characterization for therapeutic proteins
- Preferred Degree in Biochemistry, Analytical Chemistry, Protein Chemistry or related subject area
- Excellent written and verbal communication skills, ability to multitask, efficiently plan and follow through on complex projects
- A self-starter, and someone who values working in teams

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

California

Manufacturing Systems Engineer: Automation

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lie within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX Batch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

**Manufacturing Systems Engineer: Automation**

**What you will do**

Lets do this. Lets change the world. As a Manufacturing Systems Engineer, you will work with a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP DrugSubstancePlant Operations.

In this vital roleas a member of the Facilities & Engineering (F&E) Automation teamyou will work hand in hand with the capital project team to deliver robust process automation systems to operate the new plant.

Responsibilities:

- Develop and maintain the process control system on Emerson DeltaV distributed control system (DCS).

- Collaborate with key stakeholders and end-users to understand and synthesize key process requirements, and to develop solutions using Amgen standard automation platform for process automation systems.

- Provide clear documentation for delivered solutions and processes.

- Support QA partners in performing computerized systems validation in a GxP environment.

- Perform Data Integrity Assessments (DIA) in accordance with the current Amgen and industry standards.

- Support process automation systems to ensure design aligns with Amgen specifications, incorporates the latest technology, and meets safety requirements.

- Support vendor FAT to ensure that control strategy and software code meet Amgen requirements.

- Develop and maintain engineering and maintenance documentation, and associated procedures for delivered solutions and processes.

- Support commissioning and qualification efforts including Automation Installation Verification/Automation Check Out (IV/ACO) in a fast-paced environment.

- **Site Operations**

- Own and drive to completion Change Controls, CAPAs, and Deviations.

- Support technical root cause analysis, incident investigations, and troubleshooting.

- Support functional area projects focused on improving process equipment, utilities, and facilities as well as large capital projects to integrate new drug substance manufacturing technologies into the facility.

- Drive continuous improvement for process automation systems to improve operational workflows, safety, reliability, efficiency, and sustainability.

- Support day-to-day operations including rotational on-call support.

- Prepare/review Standard Operating Procedures (SOP) and cGMP documents.

- Be constantly curious and feed your passion and interests in groundbreaking technology. Use your given time to look for new and innovative ways to do business differently, better, and more cost effectively.

**What we expect from you**

We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek is an engineer with these qualifications.

**Basic Qualifications**

- High School Diploma / GED and 8 years of Engineering experience OR

- Associates Degree and 6 years of Engineering experience OR

- Bachelors Degree and 2 years of Engineering experience OR

- Masters Degree

**Preferred Qualifications**

- Degree in Electrical Engineering, Computer Science, Chemical Engineering, Biotech Engineering, or related field.

- Direct knowledge of Automation System design, experience in process control engineering and troubleshooting with GMP biopharmaceutical production facility equipment/systems automation such as media, harvest, bioreactors, solution prep, single use mixing vessels, chromatography, TFFL/TFFX, viral filtration, viral inactivation, UF/DF, depth filtration, drug substance fill, CIP/SIP, clean utilities, and integrating various OEM automation software.

- Experience in programming, installation, and lifecycle management of automation and field instrumentation technologies.

- Experience in programming, design, installation and lifecycle management of manufacturing process controls, and automation and field instrumentation technologies.

- Experience with Emerson DeltaV DCS system and ability to perform advanced troubleshooting, and system integration using OPC, Foundation Fieldbus, and Profibus technologies.

- Ability to interpret and apply GAMPs and GMPs, and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88 and S95.

- Self-directed team player able to work cross-functionally.

- Strong technical writing and communication skills.

**What you can expect from us**

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

In addition to the base salary, Amgen offers a Total Rewards Plan based on eligibility that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts

- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan

- Stock-based long-term incentives

- Award-winning time-off plans and bi-annual company-wide shutdowns

- Flexible work models, including remote work arrangements, where possible

**Apply now for a career that defies imagination**

In our quest to serve patients above all else, Amgen is the first to imagine and the last to doubt. Join us.

careers.amgen.com

\#AmgenNorthCarolina

North Carolina

Lab Design Project Engineer

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Lab Design Project Engineer**

**What you will do**

Lets do this. Lets change the world. The Laboratory Design Project Engineer provides technical leadership and subject matter expertise for the planning, design, renovation, and delivery of laboratory facilities. This role ensures laboratory environments are safe, compliant, functional, flexible, and aligned with scientific, operational, and business requirements. The Lab Design Project Engineer partners with researchers, engineers, architects, project managers, facilities teams, EHS professionals, equipment manufacturers, external design firms and global insurance partners throughout the project lifecycle.

This position requires travel to project sites and organizational locations to support project development, design reviews, field assessments, construction activities, commissioning, and stakeholder engagement.

**Key Responsibilities**

- Serve as the technical lead for laboratory planning, design standards, workflows, and facility requirements.
- Translate scientific and operational needs into laboratory design criteria, space programs, equipment requirements, and functional layouts.
- Lead or support the development and maintenance of laboratory design standards, specifications, guidelines, and standard details.
- Review laboratory design packagesincluding concepts, layouts, drawings, specifications, and equipment plansfor functionality, safety, constructability, and compliance.
- Ensure designs address laboratory ventilation, containment, biosafety, chemical safety, ergonomics, utilities, waste handling, material flow, security, and emergency response needs.
- Collaborate with users and stakeholders to define current and future laboratory capacity, flexibility, adjacencies, and workflow requirements.
- Lead technical aspects of capital projects from early feasibility and programming through design, construction, commissioning, qualification, and occupancy.
- Travel as needed to support site assessments, project meetings, design workshops, construction reviews, commissioning, and operational-readiness activities.
- Coordinate with Engineering, EHS, Facilities, Quality, Operations, external consultants, FM Insurance, and construction teams to resolve technical issues and manage design decisions.
- Evaluate laboratory equipment requirements and integration needs, including utilities, controls, automation, and supporting infrastructure.
- Identify design risks, recommend practical mitigations, and support risk assessments associated with laboratory operations and facility modifications.
- Support commissioning and turnover activities to confirm laboratory systems and spaces meet intended use and operational requirements.
- Monitor industry practices, codes, standards, and emerging laboratory design technologies; incorporate relevant improvements into organizational standards.
- Provide technical mentoring and laboratory design expertise for project teams and less experienced engineers.

**Required Qualifications**

- Bachelors degree in engineering, architecture, laboratory science, facilities management, or a related technical discipline.
- Significant experience in laboratory design, laboratory operations, engineering, architecture, facilities, or capital project delivery.
- Demonstrated knowledge of laboratory planning principles, including space programming, workflow design, equipment integration, and utility requirements.
- Working knowledge of applicable building codes, fire and life-safety requirements, EHS expectations, and relevant laboratory standards.
- Ability to interpret architectural and engineering drawings, specifications, and design documents.
- Strong project execution, problem-solving, communication, stakeholder-management, and technical-writing skills.
- Ability and willingness to travel as required to support projects and site-based stakeholders.
- Ability to manage competing priorities and influence decisions across multidisciplinary teams.

**Success Measures**

- Laboratory designs meet user requirements, safety expectations, regulatory needs, and project objectives.
- Projects are delivered with reduced design rework, operational disruptions, and avoidable scope changes.
- Laboratory standards are current, practical, consistently applied, and support scalable project delivery.
- Stakeholders receive timely, clear, technically sound guidance throughout the project lifecycle.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is a collaborate leader with these qualifications

**Basic Qualifications:**

- Doctorate degree and 2 years of engineering or laboratory science experience OR
- Masters degree and 4 years of engineering or laboratory science experience OR
- Bachelors degree and 6 years of engineering or laboratory science experience OR
- Associates degree and 10 years of engineering or laboratory science experience OR
- High school diploma / GED and 12 years of engineering or laboratory science experience

**Preferred Qualifications:**

- Advanced degree or professional certification in engineering, architecture, laboratory planning, safety, or a related field.
- Experience designing regulated laboratory environments, such as pharmaceutical, biotechnology, clinical, research, manufacturing, or quality-control laboratories.
- Familiarity with GMP, GLP, biosafety, chemical hygiene, and commissioning or qualification practices.
- Experience with laboratory ventilation systems, fume hoods, biosafety cabinets, cleanrooms, containment systems, and specialized laboratory utilities.
- Professional licensure or credentials such as PE, RA, EIT, LEED AP, or laboratory-planning certification.

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Process Development Sr Scientist

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Process Development Sr Scientist**

**What you will do**

Lets do this. Lets change the world. In this vital role you will join the pivotal synthetic Attribute Sciences team, part of the integrated Pharmaceutical Attribute Sciences (iPAS) department, located in Thousand Oaks, CA. This team plays a crucial role in pivotal phase analytical development, including method development, validation, transfer, process and product development support, and GMP testing of drug substances and drug products.

The analytical scientist will work closely with a team of analysts and scientists responsible for the technical aspects of developing analytical tools to gain understanding of key quality attributes in product and process for late phase synthetic programs across small molecules, synthetic peptides, siRNA, and synthetic components of conjugates. The analytical scientist will integrate and optimally utilize platform and in-depth product attribute knowledge to advance Amgen products and ensure success through pivotal clinical phases to marketing authorization application.

**Key Responsibilities:**

- Define analytical control strategies and implement methodologies to support the development of late-phase clinical programs, with a strong ability to articulate the challenges and complexities associated with analytical control strategy development.
- Develop, optimize, authorize and validate analytical methods for attribute understanding and characterization across synthetic modalities, including small molecules, synthetic peptides, siRNA, and the synthetic components of antibodydrug conjugates.
- Collaborate closely with drug substance and drug product process development colleagues to achieve project objectives.
- Provide analytical data to support drug substance and drug product development, including purity analysis, chiral purity and structure elucidation using mass spectrometry.
- May lead activities and method transfer to contract manufacturing organization (CMO) or contract testing lab (CTL). Review and approve protocols, reports from CMO and CTL.
- Support project team lead to author technical reports and analytical Chemistry, Manufacturing and Controls (CMC) sections in regulatory documents.
- May lead and mentor a small group of scientists.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The dynamic professional we seek is an individual with these qualifications.

**Basic Qualifications:**

- Doctorate degree PhD OR PharmD OR MD \[and relevant post-doc where applicable\]
  OR
- Masters degree and 3 years of Scientist experience
  OR
- Bachelors degree and 5 years of Scientist experience

**Preferred Qualifications:**

- PhD in Analytical Chemistry, Organic Chemistry, Physical Chemistry, Material Sciences, Pharmaceutical Sciences, or related discipline.
- 2+ years post-PhD experience in the pharmaceutical or biotech industry, focusing on process and product development, and analytical method development for drug substances and products.
- Experience in conjugates method development, characterization, and analytical control strategy especially having mass spectroscopy (MS) experience.
- Strong understanding of synthetic molecule analysis and structure elucidation informed by knowledge of organic chemistry.
- Hands on experience in method development, validation, and transfer for in-process, release, and stability testing
- Proficiency in a broad spectrum of structure elucidation and physicochemical techniques including MS, UV, NMR, FTIR, etc.
- Familiarity with USP monographs and chapters, and ICH/FDA guidance documents related to analytical method transfer and validation, impurities, mutagenic impurities, etc.
- Solid understanding of GLP and GMP requirements and their application in a phase appropriate manner
- Experience in technical transfer for non-GMP and GMP production and testing to external contract organizations, able to manage deliverables against timelines.
- Excellent communication skills and ability to provide cross-functional leadership and guidance to CMC and non-clinical teams, e.g. informing and defending the Quality Target Product Profile
- Ability to work effectively in cross-functional teams, and across various geographic locations in different time zones.
- Excellent technical writing skills with attention to detail in authoring methods, specifications, technical reports, and regulatory filing documents

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Grad Intern Machine Learning Engineer Technology, AI & Data (Summer 2027)

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Grad Intern Machine Learning Engineer Technology, AI & Data**  **(Summer 2027)**

**What You Will Do**

Lets do this. Lets change the world. During this internship, you will acquire the valuable hands-on skills and foundational experience needed to become a professional in your chosen field.

This role requires you to assist in the design, development, and testing of scalable data pipelines for data ingestion and transformation from multiple data sources into enterprise data lakes and warehouses. Responsibilities may include:

- Work closely with expert data engineers and scientists to clean, prepare, and analyze structured and unstructured data
- Support the development and automation of model training, evaluation, and deployment pipelines
- Help explore and analyze pharmaceutical commercial datasets for data-driven insights
- Participate in the design of informative visualizations and dashboards for internal stakeholders
- Learn and apply statistical techniques including hypothesis testing, regression, and classification
- Collaborate with the team on implementing and monitoring ML models in production environments
- Contribute to the documentation of technical processes, models, and tools.
- Experiment with new tools and techniques in data engineering and ML operations (MLOps)
- Participate in agile ceremonies such as sprint planning and retrospectives to understand team workflow

Program Eligibility Requirements

- Must be available to work a full-time schedule.
- Expected continued enrollment in an accredited college or university following the internship program / co-op
- Student must be located in the United States for the duration of the internship program
- Must be available to accept and commit to future full-time employment by July 2028, if offered

**What We Expect of You**

We are all different, yet we all use our unique contributions to serve patients. The passionate and driven individual we seek is exemplifies the following qualifications:

**Basic Qualifications:**

Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:

- 18 years or older
- Graduated with a bachelors degree from an accredited college or university
- Currently enrolled in an MBA program for an MBA internship OR a Masters program for a Masters internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Masters OR Pharm D OR Ph.D. program before the internship starts

**Preferred Qualifications:**

- In the process of completing the first year of a Masters program with concentration in Information Technology, Computer Science (e.g., CS, CPE, SE), Engineering, Business, or related field
- 1 or more years relevant work experience
- Biotechnology, pharmaceutical or health care industry experience
- Intermediate knowledge of Microsoft Word, Excel and Power Point
- Strong interpersonal, project management, analytical and quantitative skills
- Demonstrated personal initiative, self-motivation, flexibility, adaptability and resourcefulness
- Ability to operate independently, across functional lines, and with both internal and external customers
- Foundational experience in Python or R, including use of libraries for data manipulation (e.g., pandas, NumPy), visualization (e.g., matplotlib, seaborn), and machine learning (e.g., scikit-learn, XGBoost)
- Exposure to cloud platforms such as AWS, GCP, or Azure (coursework or personal projects)
- Basic understanding of SQL and experience querying data from relational or big data sources
- Interest or coursework in NLP, time-series analysis, or statistical modeling
- Familiarity with version control tools (e.g., Git) and collaborative coding practices
- Awareness of tools like Databricks, Apache Spark, or Apache Airflow is a plus
- Strong communication skills to optimally share technical findings with diverse audiences
- Coursework in one or more of the following areas: Business Systems analysis, Lean, Agile (SCRUM) and other SDLC processes, Software Development, Database Modeling, Web Design and Development, IT Management, Management of Cloud based application, B2B Collaboration, Enterprise systems such as configuration and management of ERP, CRM systems

**What You Can Expect of Us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $35.34 - $41.20 per hour.

- Build a network of colleagues that will endure and grow throughout your time with us and beyond.
- Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
- Participate in executive and social networking events, as well as community volunteer projects.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com - Please search for Keyword R-255743**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

District of Columbia

Undergrad Intern Software Engineer Technology, AI & Data (Summer 2027)

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Undergrad Intern Software Engineer Technology, AI & Data (Summer 2027)**

What You Will Do

Lets do this. Lets change the world. During this internship, you will acquire the valuable hands-on skills and foundational experience needed to become a professional in your chosen field.

This role employs software development, configuration and design techniques that ensure alignment to software development standards, performance efficiency, reliable and maintainable code, and self-documenting programs. Candidates should demonstrate a basic understanding of software development methodologies and techniques. Responsibilities may include:

- Developing, testing, debugging, and detailing components of applications
- Developing project plans
- Transforming basic business processes into programming logic

Program Eligibility Requirements

- Expected completion of one year of study from an accredited college or university prior to the internship commencing
- Expected continued enrollment in an accredited college or university following the internship program
- Student must be located in the United States for the duration of the internship program
- Must be available to work a full-time schedule.
- Must be available to accept and commit to future full-time employment by July 2028, if offered

What We Expect of You

We are all different, yet we all use our unique contributions to serve patients. The passionate and driven individual we seek exemplifies the following qualifications:

**Basic Qualifications:**

Amgen requires that all individuals applying for an undergrad internship or a co-op assignment at Amgen must meet the following criteria:

- 18 years or older
- Currently enrolled in a full-time Bachelors Degree program from an accredited college or university with a 3.0 minimum GPA or equivalent

**Preferred Qualifications**

- Degree concentration(s) in Information Technology, Computer Science (e.g., CS, CPE, SE), Engineering, Business, or related field
- Biotechnology, pharmaceutical or health care industry experience
- Intermediate knowledge of Microsoft Word, Excel and Power Point
- Strong interpersonal, project management, analytical and quantitative skills
- Proficient in one of the coding languages (Python, Java, Scala, SQL)
- Detail oriented
- Demonstrated personal initiative, self-motivation, flexibility, adaptability and resourcefulness
- Ability to operate independently, across functional lines, and with both internal and external customers
- Coursework in one or more of the following areas:
- Business Systems analysis, Lean, Agile (SCRUM) and other SDLC processes, Software Development, Database Modeling, Web Design and Development, IT Management, Management of Cloud based application, B2B Collaboration, Enterprise systems such as configuration and management of ERP, CRM systems

What You Can Expect of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $28.87 per hour.

- Build a network of colleagues that will endure and grow throughout your time with us and beyond.
- Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
- Participate in executive and social networking events, as well as community volunteer projects.

Apply now and make a lasting impact with the Amgen team.

**careers.amgen.com** Please search for Keyword R-255719

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Undergrad Intern Machine Learning Engineer Technology, AI & Data (Summer 2027)

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Undergrad Intern Machine Learning Engineer Technology, AI & Data**  **(Summer 2027)**

**What You Will Do**

Lets do this. Lets change the world. During this internship, you will acquire the valuable hands-on skills and foundational experience needed to become a professional in your chosen field.

This role requires you to assist in the design, development, and testing of scalable data pipelines for data ingestion and transformation from multiple data sources into enterprise data lakes and warehouses. Responsibilities may include:

- Work closely with expert data engineers and scientists to clean, prepare, and analyze structured and unstructured data
- Support the development and automation of model training, evaluation, and deployment pipelines
- Help explore and analyze pharmaceutical commercial datasets for data-driven insights
- Participate in the design of informative visualizations and dashboards for internal stakeholders
- Learn and apply statistical techniques including hypothesis testing, regression, and classification
- Collaborate with the team on implementing and monitoring ML models in production environments
- Contribute to the documentation of technical processes, models, and tools.
- Experiment with new tools and techniques in data engineering and ML operations (MLOps)
- Participate in agile ceremonies such as sprint planning and retrospectives to understand team workflow

**Program Eligibility Requirements**

- Expected completion of one year of study from an accredited college or university prior to the internship commencing
- Expected continued enrollment in an accredited college or university following the internship program
- Student must be located in the United States for the duration of the internship program
- Must be available to work a full-time schedule.
- Must be available to accept and commit to future full-time employment by July 2028, if offered

**What We Expect of You**

We are all different, yet we all use our unique contributions to serve patients. The passionate and driven individual we seek exemplifies the following qualifications:

**Basic Qualifications:**

Amgen requires that all individuals applying for an undergrad internship or a co-op assignment at Amgen must meet the following criteria:

- 18 years or older
- Currently enrolled in a full-time Bachelors Degree program from an accredited college or university with a 3.0 minimum GPA or equivalent

**Preferred Qualifications**

- Degree concentration(s) in Information Technology, Computer Science (e.g., CS, CPE, SE), Engineering, Business, or related field
- Biotechnology, pharmaceutical or health care industry experience
- Intermediate knowledge of Microsoft Word, Excel and Power Point
- Strong interpersonal, project management, analytical and quantitative skills
- Demonstrated personal initiative, self-motivation, flexibility, adaptability and resourcefulness
- Ability to operate independently, across functional lines, and with both internal and external customers
- Foundational experience in Python or R, including use of libraries for data manipulation (e.g., pandas, NumPy), visualization (e.g., matplotlib, seaborn), and machine learning (e.g., scikit-learn, XGBoost)
- Exposure to cloud platforms such as AWS, GCP, or Azure (coursework or personal projects)
- Basic understanding of SQL and experience querying data from relational or big data sources
- Interest or coursework in NLP, time-series analysis, or statistical modeling
- Familiarity with version control tools (e.g., Git) and collaborative coding practices
- Awareness of tools like Databricks, Apache Spark, or Apache Airflow is a plus
- Strong communication skills to optimally share technical findings with diverse audiences
- Coursework in one or more of the following areas: Business Systems analysis, Lean, Agile (SCRUM) and other SDLC processes, Software Development, Database Modeling, Web Design and Development, IT Management, Management of Cloud based application, B2B Collaboration, Enterprise systems such as configuration and management of ERP, CRM systems

**What You Can Expect of Us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $28.87 per hour.

- Build a network of colleagues that will endure and grow throughout your time with us and beyond.
- Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
- Participate in executive and social networking events, as well as community volunteer projects.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com** Please search for Keyword R-255709

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Process Development Senior Associate

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Process Development Senior Associate**

**What you will do**

Lets do this. Lets change the world. In this vital role you will join Amgens DSTS group within Process Development (PD) is responsible for the invention, development, and implementation of drug substance manufacturing processes and technologies to advance Amgen's exciting portfolio of synthetic and hybrid assets.

Amgen is currently seeking a talented Process Development Senior Associate to join our Drug Substance Technologies - Synthetics (DSTS) group in Thousand Oaks, California. Senior Associates in our team collaborate with chemists, process engineers, and attribute scientists to support drug substance development and manufacturing from early to late-stage development. The successful candidate will be a highly motivated and team-oriented individual with prior lab-based research experience in bioconjugation.

- Work within a drug substance team comprised of chemists, engineers, and attribute scientists to solve technical problems
- Contribute to the development of safe, robust, and cost-effective processes to manufacture synthetic and hybrid drug substances
- Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers
- Support process characterization activities, including process understanding and modeling
- Contribute to drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
- Works regularly with a supervisor to advance projects within required deadlines.
- Work cross-functionally to deliver regulatory documents and support regulatory filings
- Follows good laboratory documentation practices and standard operating procedures

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. dynamic professional we seek is an individual with these qualifications.

**Basic Qualifications:**

- Masters degree
  OR
- Bachelors degree and 2 years of Scientific experience
  OR
- Associates degree and 4 years of Scientific experience
  OR
- High school diploma / GED and 6 years of Scientific experience

**Preferred Qualifications:**

- M.S. in organic chemistry or biochemistry/chemical biology with a specialization in bioconjugation chemistry
- Prior bioconjugation experience in the biopharmaceutical or pharmaceutical industry
- Demonstrated ability to work in a chemistry laboratory with minimal supervision
- Ability to independently collect and interpret analytical results (NMR, HPLC, MS, IR, Raman, etc)
- Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on projects
- A research summary included with CV is strongly encouraged

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Sr. Engineer, Process Development

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Sr Engineer**

**What you will do**

Lets do this. Lets change the world. In this vital role you will be responsible for authoring technical reports, leading risk assessments, and contributing to regulatory documents through all phases of technology transfer and commercialization.

Position located in either Cambridge, MA or Thousand Oaks, CA.

Domestic and International Travel: up to 20%

- Technical and lab-based execution of bench and kilogram-scale experimentation and process modeling & simulation to design and optimize robust synthetic and hybrid processes.
- Critical evaluation of novel chemical processes for the identification of process improvement opportunities and requirements necessary to ensure safe and successful scale-up and tech transfer.
- Design, optimize, and deploy process models for reaction kinetics, mass transfer, separations, distillations, isolations, drying, and relevant hydrodynamic operations.
- Model and analyze the economic value and environmental impact of process synthetic processes and manufacturing concepts.
- Initiate and complete standard practices for technology transfer of synthetic processes which include drafting process transfer documents, process fit assessments, manufacturing support, risk analysis and process documentation.
- Represent organization within a multi-functional team to ensure deliverables are aligned with tech transfer timeline, such that key milestones are established and achieved.
- Apply standard and advanced engineering techniques and procedures to provide solutions to a variety of technical chemical and process issues that will be encountered during process development, tech transfer and scale-up.
- Routinely monitor manufacturing processes for performance indicators and operations. Lead problem resolution and provide troubleshooting guidance.
- Apply engineering principles and statistical analysis, including design of experiments, in-order to critically evaluate chemical processes for identification of process improvements and requirements necessary for scale up and tech transfer.
- Author, review and/or approve of process documentation needed for process validation and commercialization activities.
- Contribute to key regulatory and quality activities such as NDAs, non-conformances, process performance qualification and continued process verification.
- Provide on-the-floor support to ensure successful scale-up and facilitate rapid problem solving and decision-making.
- Lead or represent department as subject matter expert for process risk analysis.
- Work closely with process development chemists, formulation scientists, and analytical chemists to generate and interpret data to provide improved understanding and guidance for synthesis and unit operations.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

**Basic Qualifications:**

Doctorate degree

OR

Masters degree and 2 years of **Engineering Experience**

OR

Bachelors degree and 4 years of **Engineering Experience**

OR

Associates degree and 8 years of **Engineering Experience**

OR

High school diploma / GED and 10 years of **Engineering Experience**

**Preferred Qualifications:**

- Familiar with bioprocessing unit operations required to support ADCs and/or oligonucleotides, including conjugation and purification.
- Experience in developing and executing experimental plans to evaluate and develop processes to achieve optimum cost, robustness, and productivity.
- Experience related to technology transfer, scale-up and manufacturing of synthetic molecules in a regulated environment. This includes technical support for non-conformance investigations and other commercial support activities.
- Experience authoring regulatory documents for commercialization of drug substance processes: CMC Module 3, RTQs, and annual reports.
- Experience building and utilizing first-principles models (e.g., reaction kinetics, mass transfer, separations, distillations, isolations, drying, and hydrodynamics) with proficiency across several modeling platforms.
- Knowledge of analytical techniques and solid-state characterization with fluency in a wide variety of methods including HPLC, GC, MS, NMR, FTIR, LOD, TOC, FBRM, particle size determination, etc.
- Experience using data science and/or advanced statistical analysis to solve processing issues and evaluate opportunities for process improvements.
- Proficient understanding of regulatory and cGMP requirements.
- Command of lab and plant operations and associated safety practices.
- Familiarity with HPAPI processing and containment. Engineering knowledge around linker payload chemistry and scale-up.
- Strong communication and presentation skills

**What you can expect from us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Principal Manufacturing Systems Engineer Upstream/Downstream Process Automation

**HOW MIGHT**YOU**DEFY IMAGINATION?**

Youveworked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills,experience,and passion to work toward your goals? At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies, reaching over10 million patientsworldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the AmgenFleXBatch facility will combine the latest in disposable technologies with traditional stainless-steel equipment to allow for maximum flexibility in operations. TheFleXBatch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

**Principal Manufacturing Systems Engineer Upstream/Downstream Process Automation**

**What you will do**

Lets do this! Lets change the world! In this vital role, you will serve as a subject matter expert in automation engineering, driving innovation, solving complex challenges, and influencing the design and implementation of automation systems for upstream and downstream bioprocessing. You will collaborate across engineering, manufacturing, and quality teams to ensure robust, compliant, and scalable automation solutions that support 24/7 operations.

The Principal Manufacturing Systems Engineer will join the Facilities & Engineering (F&E) group. This role will partner closely with the corporate engineering team during the design, build, commissioning, and qualification phases and later transitioning to supporting daily operations for drug substance production. This role will be instrumental in developing automation domain expertise and supporting operational readiness.

Job responsibilities include:

- **Site design, construction, start-up, and operational readiness:**
  - Support design reviews while partnering closely with the corporate engineering team to represent site interests and requirements.
  - Execute and support the commissioning and qualification of process equipment automation in alignment with GMP requirements, while working in partnership with global engineering during site installation. Ensure their operational capability is aligned with manufacturing requirements and GMP regulation and on-time project delivery.
  - Collaborate with the site process engineering team to understand key process requirements and develop process control automation solutions primarily utilizing Emerson DeltaV Distributed Control System (DCS).
  - Lead commissioning and qualification efforts, including Automation Installation Verification/Automation Check Out (IV/ACO), ensuring compliance with GMP and project timelines.
  - Partner with various organizational units to support tasks including operational readiness, document reviews, deviation investigation and change controls.
  - Provide mentoring to develop and accelerate site technical automation capabilities.
- **Site Operations:**
  - Act as responsible system owner for automation systems, providing day-to-day automation support including 24 x 7 onsite/on-call support, troubleshooting, and daily automation team meetings.
  - Provide technical leadership to troubleshoot, identify and resolve process and system issues as needed.
  - Effectively collaborate with key customers and support groups (e.g. Manufacturing, Quality, Process Development, Maintenance, network partners).
  - Perform automation change assessments, implement automation system configuration changes, and support engineering and process qualification runs.
  - Lead continuous improvement initiatives including improvements to safety, reliability, efficiency, and sustainability, such as cycletimes, yields, and efficiency of unit operations in manufacturing.
  - Perform and maintain data integrity in accordance with the current Amgen and industry standards.
  - Serve as a technical mentor to junior engineers and cross-functional teams.
  - Influence automation strategy and standardization across the site and network.
  - Represent plant automation in Amgen global network forums related to automation and process control.
  - Represent automation during audits, and regulatory inspections.
  - Stay current with emerging technologies and industry trends to identify opportunities for innovation.
  - Provide strategic, tactical management, and leadership to ensure 24x7 day-to-day reliability of plant operations.
  - Up to 10% domestic/international travel

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek enjoys challenges and is motivated to help serve patients with these qualifications.

Basic Qualifications:

- Doctorate degree and 2 years of engineering experience

OR

- Masters degree and 4 years of engineering experience

OR

- Bachelors degree and 6 years of engineering experience

OR

- Associates degree and 10 years of engineering experience

Or

- High school diploma / GED and 12 years of engineering experience

And

- 2 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources

Preferred Qualifications:

- Degree in Electrical Engineering, Computer Science, Chemical Engineering or Biotech Engineering.
- Extensive experience with Emerson DeltaV, Process Control Network design including network segregation, Process Control Systems: Virtual Infrastructure design and implementation, System Integration using OPC, Foundation Fieldbus, and Profibus.
- Hands-on experience with IO-Link technology for smart sensor/actuator integration in automated manufacturing environments.
- Familiarity with Process Analytical Technology (PAT) tools and strategies for real-time process monitoring and control in biopharmaceutical manufacturing.
- Direct knowledge of integrating various OEM automation software and field instrumentation technologies.
- In-depth knowledge of industry standards such as 21 CFR Part 11, ASTM 2500, S88, S95, GAMP, GDP, and GMP.
- Experience working in a regulated environment (e.g. cGMP, OSHA, EPA, etc.), experience interacting with regulatory agencies and inspectors, and familiarity with GMP quality systems/processes such as change control, non-conformances, corrective and preventative actions, and qualifications/validation
- Experience with Tech Transfer, Process Design, and Commissioning & Qualification.
- Deep understanding of biopharmaceutical manufacturing processes including Upstream (Seed train, production Bioreactors, Harvest), and Downstream Purification (e.g. Chromatography and viral Filtration skids, UFDF), and CIP/SIP Skids.
- Ability and willingness to mentor and develop engineering staff and embrace a team-based culture that relies on collaboration for effective decision-making.
- Strong leadership, technical writing, and communication/presentation skills.
- Proven ability to influence cross-functional teams and drive technical decisions.
- Work schedule flexibility as required to support 24/7 operations, requiring occasional after-hours engineering coverage

Principal Process Engineer - Upstream/Downstream

Job Description

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX batch facility will combine the latest in disposable technologies with traditional stainless steel equipment to allow for maximum flexibility in operations The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

**PrincipalProcess Engineer- Upstream/Downstream**

**What you will do**

In this vital role you will be joining the Facilities & Engineering (F&E) group to partner closely with the corporate engineering team to design, build, commission, and qualify new equipment and systems needed for drug substance production.You will lead technical projects, and drive innovation in product design and manufacturing processes. You will solve complex engineering problems, optimize processes, and ensure the company's engineering efforts align with strategic objectives. You will also provide leadership and guidance to the engineering team supporting 24/7 manufacturing and facility operations.

- **Site design, construction, start-up, and operational readiness:**

- Support the design and buildof manufacturing equipment systems by aligning design review processes and documents with site requirements, including equipment design and sizing, architecture and electrical distribution, and piping and instrumentation diagrams.

- Support factory acceptance testing working in partnership with global engineering during site installation, including reviewing protocols and resolving punch list items.

- Work with capital project team to ensure systems are installed and operatingsafely and comply with pertinent environmental health/safety practice, rules and regulations as well as Amgen global engineering requirements.Ensure that systems are installed per the design requirements.

- Execute and guide the commissioning and validation of systems to ensure their operational capability is aligned with manufacturing requirements and GMP regulation and on-time project delivery. Support execution of engineering and performance qualification runs while providing hypercare support as needed.

- Perform engineering assessments for plant equipment operations,implementing equipment modifications, and supporting engineering runs in support of new product/technology introductions as required.

- **Site Operations:**

- Provide system ownership for Upstream and/orDownstream Drug substance process equipment, areas, and systems providing end-to-end support for operations.

- Serve as a main point of contact for Process and equipment engineering function.

- Effectively collaborate with key customers and support groups(e.g. Manufacturing, Quality, Process Development, Maintenance, network partners) to ensure reliable plant operations.

- Work with original equipment manufacturers for breakdown and planned maintenance of process equipment as applicable.

- Leadidentifying and implementing engineering-based improvements or upgrades to processequipment systems.This may include developing business cases for improvements, identifying design requirements, and translating these requirements into process equipment/system design, specifications, and supporting the construction, startup, and validation of equipment.

- Develop master maintenance programs for equipment, ensure the availability of spare parts, andcoordinate maintenance activities to ensure systems are in proper working order.

- Ensure plant readiness and quality and regulatory compliance for internal audits, external agency audits, and partner audits for the process equipment.

- Providetechnical mastery andproblem-solvingleadership to proactivelyreduce production downtime. This includes leading technical root cause analysis and implementation of corrective/preventiveactions for families of systems.

- Lead new product/technology introductions by performing engineering assessments,equipment performance risk assessments, identifying gaps and owning their remediation, implementing equipment modifications, and supporting engineering runs.

- Provide mentorship and coaching to junior engineering peers when they encounter challenges and roadblocks, as appropriate.

- Demonstrate knowledge and understanding of how building and process automation systems interact with and impact process equipment and be able to effectively communicate automation issues and needs to support groups and to management.

- Effectively communicate the correct level of detail for process risks in a timely manner to support groups and leadership.

- Provide rotational on-call support and ensure 24x7 day-to-day reliability of Upstream and Downstream systemsfor plant operations.

- Up to 10% domestic/international travel.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The engineering professional we seek enjoys challenges and is motivated to help serve patients with these qualifications.

**Basic Qualifications:**

- Doctorate degree and 2 years of engineering experience

OR

- Masters degree and 4 years of engineering experience

OR

- Bachelors degree and 6 years of engineering experience

OR

- Associates degree and 10 years of engineering experience

Or

- High school diploma / GED and 12 years of engineering experience

And

- 2 years of managerial experience directly managing people and/or leadership experience leading teams, projects, programs or directing the allocation of resources

**Preferred Qualifications:**

- Bachelors degree in Chemical or Mechanical Engineering or related technical field..

- 8+ years' of relevant work experience with 5+ years' experience in Biopharmaceuticaloperations/manufacturing environment focused on process and plant engineering function.

- Demonstrated people and/or project management and leadership experience.

- Direct knowledge of design and troubleshooting with GMP Biopharmaceutical Productionfacility equipment/systems with direct experience with Upstream and Downstream purification equipment such as cell culture reactors, centrifugation, chromatography, viral filtration skids, and UFDF skidsas well as other equipment needed to support these processes such as autoclaves, clean in place (CIP) systems, washers, clean steam, water for injection, etc.

- Experience with designing and operating equipment used in biopharmaceutical manufacturing.

- Experience with Tech Transfer, Process Design, and Commissioning & Qualification.

- Experience working in a regulated environment (e.g. cGMP, OSHA, EPA, etc.) andwith GMP quality systems/processes such as change control, non-conformances,corrective and preventative actions, and qualifications/validation

- Understanding of safety requirements working in a GMP Biopharmaceutical productionfacility.

- Independent, ambitious, organized, able to multi-task in project environments, and skilled incommunication, facilitation, and teamwork.

- Strong leadership, technical writing, and communication/presentation skills

- Work schedule flexibility as required to support 24/7 operations.

- Ability for domestic/international travel.

Senior Director - Head of Process Engineering (Synthetic Drug Substance Process Development)

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Senior Director - Head of Process Engineering (Synthetic Drug Substance Process Development)**

**What you will do**

Lets do this. Lets change the world. Would you like to lead a highly motivated team of process development experts and professionals to positively impact patients lives? Amgen is seeking a Senior Director to serve as our Head of Process Engineering within the Drug Substance Technologies Synthetics (DSTS) organization. In this role, the Senior Director will be a member of the DSTS Leadership Team and be accountable to drive technical and strategic solutions for the development, characterization, technology transfer, and lifecycle management of synthetic and hybrid drug substance manufacturing processes for our early- and late-phase clinical and commercial portfolios. In this on-site role located in either Cambridge, MA or Thousand Oaks, CA you will lead and develop a global, multisite organization of 30+ scientists and engineers, provide strategic oversite to ensure program success, and foster a culture of safety, quality, compliance, and technical excellence. In addition, you will represent the DSTS organization in our cross functional collaborations to ensure the successful implementation and performance of our clinical/commercial drugs substance manufacturing processes.

**Key Responsibilities:**

- Lead a global organization with accountability for the capability of our small molecule/hybrid process engineering team, talent development, succession planning, performance management, and fostering a culture of innovation, collaboration, and operational excellence.
- Provide strategic oversight for the advancement of our synthetic & hybrid portfolio from early-phase clinical through commercial advancement and lifecycle management.
- Establish and implement improved engineering business and technology platforms from early-phase through commercial process development, process characterization, lifecycle management, and technology transfer.
- Strengthen the technical capabilities and innovative practices across the engineering organization.
- Author and review global regulatory filings (IND/INDa/MAA) and responses to regulatory agency questions.
- Foster a culture of safety, quality, and compliance while ensuring adherence to standard operating procedures.
- Recruit, develop, and retain a high-performing and diverse team.
- Manage portfolio prioritization, resource allocation, and budget.
- Partner with manufacturing and external network collaborators to enable successful process technology transfer, validation and clinical/commercial supply.
- Engage directly with the leadership and technical teams of our external partners and contract development & manufacturing organization (CDMOs).
- Drive ideation, development, and deployment of innovative and differentiating technologies that decrease development time and create more robustness and cost-effective processes.
- Identify process improvement opportunities to increase robustness and reduce cost over the lifecycle of commercial drug substance processes.
- Contribute to Amgens scientific eminence through publications, patents, and participation in external conferences and forums.
- Serve as a member of the Drug Substance Technology Synthetics Leadership Team and contribute to business, organizational, and changemanagement strategies.

**Travel Requirements:**

- May require approximately 10-20% travel (domestic and international).

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

**Basic Qualifications:**

- Doctorate degree and 5 years of scientific process development experience, OR
- Masters degree and 9 years of scientific process development experience, OR
- Bachelors degree and 11 years of scientific process development experience, AND

In addition to meeting at least one of the above requirements, you must have at least 5 years of experience directly managing people and/or organizational leadership experience leading teams, projects, or programs. Your managerial experience may run concurrently with the required technical experience referenced above.

**Preferred Qualifications:**

- PhD in Chemical Engineering or related discipline.
- 10+ years of experience in synthetic/hybrid pharmaceutical process development.
- Minimum of 5 years of experience directly managing people and managing an organization of \>20 staff members.
- Subject matter expert in small molecule, peptide, oligonucleotide, and/or bioconjugate process development within the pharmaceutical industry.
- Expertise in cGMP operations, technology transfer, scale-up, and commercialization of active pharmaceutical ingredients.
- Experience managing technology transfer and manufacturing at contract manufacturing organizations (CMOs).
- Experience with quality risk management processes.
- Working knowledge of pertinent regulatory and ICH guidance.
- Experience with drafting regulatory filings (IND, MAA), annual product reviews (APR), briefing documents, and responses to regulatory questions.
- Fluency in synthetic and hybrid drug substance development including process design, optimization, characterization, validation (PPQ).
- Proven ability to provide scientific and engineering leadership on complex crossfunctional programs.
- Demonstrated experience in statistical data analysis, technical decisionmaking, and quality by design principles.
- Experience with executive-level communication.
- Track record of developing talent through coaching, mentoring, and feedback.
- Active engagement in the scientific community (publications, patents, industry forums).

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Process Development Senior Associate**

**What you will do**

Lets do this. Lets change the world. In this vital role you will join our Pivotal Drug Product Technologies group in Thousand Oaks, CA. This group supports drug product commercial formulation development as well as formulation/fill/finish process development for Amgens Late-Stage biologics. The Sr. Associate will work closely with a team of engineers and scientists responsible for the technical aspects of Amgens drug product commercialization and lifecycle management.

- Participate in the planning and design of formulation and process development studies by applying basic science/engineering skills and prior knowledge
- Participate in the execution and documentation of laboratory studies with a high degree of accuracy (e.g. UF/DF, filtration, freeze-thaw, stability)
- Evaluate product and process performance through analytical testing (e.g. U/HPLC, particle analysis, moisture content)
- Build a wide range of data and analytics solutions, from available commercial dashboarding tools such as TIBCO Spotfire, MS Smartsheet
- Perform data analysis using statistical analysis software (e.g. JMP, SAS, etc.)
- Apply advanced digital tools to automate data structuring, analyze large and diverse datasets and build intuitive visualizations.
- Author/review technical protocols and reports
- Participate in team meetings by sharing study designs, results and technical challenges

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

**Basic Qualifications:**

Masters degree

OR

Bachelors degree and 2 years of **Scientific** experience

OR

Associates degree and 4 years of **Scientific** experience

OR

High school diploma / GED and 6 years of **Scientific** experience

**Preferred Qualifications:**

- Degree in Chemical Engineering, Biomedical Engineering, Biochemistry, Biotechnology, Pharmaceutics or related field
- 1+ years of experience in pharmaceuticals/biotechnology that includes process characterization, formulation development, equipment design and implementation, technology transfers
- Familiarity with pharmaceutical/biotechnology process development
- Knowledge of Drug Product unit operations (i.e. ultrafiltration/diafiltration, filling, filtration, mixing, etc.) and experience with relevant analytical techniques (i.e. SEC, CEX, HIAC, MFI)
- Understanding of physical/chemical stability of proteins and how process-related stresses impact molecule attributes and product quality. Familiarity with ADCs is preferred.
- Proficiency in at least one statistical software package (e.g. SAS, JMP or Minitab)
- Experience with programming (e.g. Python, R, MATLAB) and database languages (e.g. SQL), as well as data visualization tools (e.g. Tableau, Spotfire, D3js)
- Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and align with company policies
- Self-motivation, adaptability and a positive attitude
- Critical thinking, problem solving and independent research skills
- Good organizational skills with strong attention to detail
- Excellent communication (oral and written)

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

Process Development Senior Principal Scientist

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Process Development Senior Principal Scientist**

**What you will do**

Lets do this. Lets change the world. In this vital role you will join our Pivotal Drug Product Technologies group in Thousand Oaks, CA. This group supports drug product commercial formulation development as well as formulation/fill/finish process development for Amgens Late-Stage biologics.

The Senior Principal Scientist will provide technical and project leadership while integrating information generated by functionally diverse teams to ensure success through the commercialization process.

The ideal candidate will bring hands-on experience in ADC drug product formulation anddrug product process development, includinga mechanisticunderstanding of linker-payload attributes,stability/process-relevant degradation pathways, and analytical strategies used to characterize ADCCQAs. This candidate will integrate formulation, analytical, and process data to guide product design,applycutting-edgetechnologies (including AI/ML), and collaborate cross-functionally to deliver high-quality, stable, and manufacturable drug products for developmentin a fast-paced environment.

- Lead planning, design, execution, and documentation of laboratory studies related to drug product design, formulation, and process development, and tech transfer
- Deliver progress reports and presentations to ensure management awareness and engagement of the status, progress, and future program and functional needs
- Author and review guideline documents, technical protocols, reports, product impact assessments, regulatory submissions, and developing responses to regulatory questions
- Develop and characterize liquidandlyophilizedformulations for biologics, with particular emphasis on ADC drug product formulation, handling, and lab-scale sterile filling.
- Lead internal and external technology transfer activities, including collaboration with CMOs/CDMOs, process fit assessments, and troubleshooting during manufacturing campaigns.
- Apply machine learning, AI, and data science to predictive modeling, workflow acceleration, and decision-making.
- Serve as a Drug Product Team Lead of a matrixed team to develop strategy in support of commercialization and life cycle management of Amgens pipeline
- Manage team of engineers and scientists to advance program and functional objectives
- Work effectively in a highly matrixed team environment to influence and inspire change, efficiency, and foster positive relationships
- Ability to travel domestically and internationally up to 10% of the time

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a leader with these qualifications.

**Basic Qualifications:**

Doctorate degree PhD OR PharmD OR MD and 2 years of **Scientific** experience

OR

Masters degree and 5 years of **Scientific** experience

OR

Bachelors degree and 7 years of **Scientific** experience

**Preferred Qualifications:**

- Advanced degree in Engineering, Pharmaceutics, Biotechnology, Material Science or related subject area
- 8+ years of experience in pharmaceuticals/biotechnology
- 5+ years of experience that includes elements of formulation and fill/finish process development, process characterization, technical transfers to manufacturing sites, and statistical design and analysis of experiments, and regulatory authoring
- Proven experience in formulation development, stability testing, and fill/finish operations for biologics; direct ADC drug product formulation experience is strongly preferred.
- Demonstrated understanding of ADC drug product development considerations, including linker-payload stability, drug-to-antibody ratio, free drug or payloaddegradation, quality attributes, and product/process comparability.
- Experience integrating formulation, stability, and analytical data to advance ADC candidates is highly desirable.
- Strong foundationin analytical and biophysical techniques relevant to ADCs and biologics (e.g., UPLC/HPLC, SEC, IEX, RP-HPLC, HIC, CE-SDS, subvisible particle analysis, etc.).
- Technical leader with demonstrated results driving forward programs
- Experience in drug product regulatory strategy, RTQs, and agency engagement
- Knowledge of, and hands-on experience with, bringing new biotech products to market, across various dosage forms and device delivery systems
- Experience with programming (e.g. Python, R, MATLAB) and database languages (e.g.
- SQL), as well as data visualization tools (e.g. Tableau, Spotfire, D3js)
- Proficiency in at least one statistical software package (e.g. SAS, JMP or Minitab)
- Experience participating and leading global multi-functional teams
- Outstanding knowledge of formulation, aseptic processing and manufacturing of biotechnology products, vials, syringes, cartridges, devices, disposables, modeling, and the associated GMP/Device documentation and regulatory filings
- Strong problem solving and effective multi-functional interpersonal skills
- Willing and able to learn new technologies at a rapid pace

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Grad Intern - Operations Process Development (Summer 2027)

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Grad Intern - Operations Process Development (Summer 2027)**

**What You Will Do**

Lets do this. Lets change the world. Operations is one of the three foundational functions at Amgen with a mission to be consistent and efficient in delivering safe and effective medicines around the world. Operations manufactures and delivers Amgen therapeutics to our patients. Made up of five subfunctions: Global Supply Chain, Process Development, Quality, Manufacturing, and Engineering, and spread across several sites, Operations aspiration is simple: Ensure patients have access to the Amgen products they need. Every patient, every time.

Process Development (PD) is the department within Operations that takes molecules from Research & Development and turns them into products which can be manufactured for therapeutic use. With the support of their hiring manager, the PD intern will complete a technical project in one of the following areas: Drug Substance Technologies, Attribute Sciences, Manufacturing and Clinical Supply, Drug Product Technologies, or Combination Product Operations. The intern will get the chance to be exposed to scientific and/or business processes within Amgen as well as analyze and interpret data into meaningful, business-influencing outcomes, and then communicate this process to their team in a clear and compelling manner.

In conjunction with the project work, interns will have the opportunity for professional development through training sessions, an Executive Speaker Series, lab and facilities tours, one-on-one mentoring, and various networking events. Interns will also be able to interact with peers at Amgen-sponsored social events.

**Example projects from previous internships:**

- **Drug Substance Technology** Development of Single-Pass Tangential Flow UF/DF Unit Operation for Production of Ultra-High Concentration Drug Substance
- **Attribute Sciences** Advancement of Activity Assays for Key Residual Host Cell Proteins
- **Drug Product Technology** Using Mass Spectrometry as an In-line Process Analytical Tool for Lyophilization
- **Combination Product Operations** Gathering Patient and Internal Stakeholder Insights to Improve Combination Products and Processes
- **Manufacturing and Clinical Supply** Tactical Project Management Standardization for Commercial Drug Product Tech Transfers

**Program Eligibility Requirements**

- Must be available to work a full-time schedule.
- Expected continued enrollment in an accredited college or university following the internship program / co-op
- Student must be located in the United States for the duration of the internship program

**What We Expect of You**

We are all different, yet we all use our unique contributions to serve patients. The graduate intern we seek is a collaborative team-player who exemplifies the following qualifications:

**Basic Qualifications:**

Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:

- 18 years or older
- Graduated with a bachelors degree from an accredited college or university
- Currently enrolled in an MBA program for an MBA internship OR a Masters program for a Masters internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Masters OR Pharm D OR Ph.D. program before the internship starts

**Preferred Qualifications:**

- Currently enrolled in a Masters program for a Masters internship from an accredited college or university and completion of the first year Masters program before the internship starts
- Degree concentration(s) in Molecular Biology, Chemical Engineering, OR related discipline
- 2-4 years of lab experience
- Strong basic lab skills
- Ability to learn new experimental methods
- Strong attention to detail
- Ability to conduct research
- Ability to manage multiple projects consecutively
- Demonstrated ability to bring structure to complex problems, pragmatic scoping and problem-solving approach, ability to objectively evaluate options/trade-offs and develop executive management-level recommendations
- Knowledge and understanding of Good Manufacturing Practices (GMP) and regulatory policies

**What You Can Expect of Us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $35.34 - $41.20 per hour.

- Build a network of colleagues that will endure and grow throughout your time with us and beyond.
- Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
- Participate in executive and social networking events, as well as community volunteer projects.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com - Please search for Keyword R-254519**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Undergrad Intern - Operations Process Development (Summer 2027)

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Undergrad Intern - Operations Process Development (Summer 2027)**

**What You Will Do**

Lets do this. Lets change the world. Operations is one of the three foundational functions at Amgen with a mission to be consistent and efficient in delivering safe and effective medicines around the world. Operations manufactures and delivers Amgen therapeutics to our patients. Made up of five subfunctions: Global Supply Chain, Process Development, Quality, Manufacturing, and Engineering, and spread across several sites, Operations aspiration is simple: Ensure patients have access to the Amgen products they need. Every patient, every time.

Process development (PD) is the department within Operations that takes molecules from Research & Development and turns them into products which can be manufactured for therapeutic use. With the support of their hiring manager, the PD intern will complete a lab-based project in one of the following areas: Drug Substance Technologies, Attribute Sciences, Manufacturing and Clinical Supply, Digital Strategy & Capabilities, Drug Product Technologies, or Combination Product Operations. The intern will be responsible for rigorously conducting and documenting their experiments as well as analyzing and interpreting data into meaningful, business-influencing outcomes, and then communicating this process to their team in a clear and compelling manner.

In conjunction with the project work, interns will have the opportunity for professional development through training sessions, an executive speaker series, lab and facilities tours, one-on-one mentoring, and various networking events. Interns will also be able to interact with peers at Amgen-sponsored social events.

**Example projects from previous internships:**

- **Drug Substance Technology** Development of Single-Pass Tangential Flow UF/DF Unit Operation for Production of Ultra-High Concentration Drug Substance
- **Attribute Sciences** Advancement of Activity Assays for Key Residual Host Cell Proteins
- **Drug Product Technology** Using Mass Spectrometry as an In-line Process Analytical Tool for Lyophilization
- **Combination Product Operations** Gathering Patient and Internal Stakeholder Insights to Improve Combination Products and Processes
- **Manufacturing and Clinical Supply** Tactical Project Management Standardization for Commercial Drug Product Tech Transfers

**Program Eligibility Requirements**

- Expected completion of one year of study from an accredited college or university prior to the internship commencing
- Expected continued enrollment in an accredited college or university following the internship program
- Student must be located in the United States for the duration of the internship program
- Must be available to work a full-time schedule.
- Must be available to accept and commit to future full-time employment by July 2028, if offered

**What We Expect of You**

We are all different, yet we all use our unique contributions to serve patients. The undergraduate intern we seek is a collaborative team-player that exemplifies the following qualifications:

**Basic Qualifications:**

Amgen requires that all individuals applying for an undergrad internship or a co-op assignment at Amgen must meet the following criteria:

- 18 years or older
- Currently enrolled in a full-time Bachelors Degree program from an accredited college or university with a 3.0 minimum GPA or equivalent

**Preferred Qualifications**

- Degree concentration(s) in Biology, Chemistry, Biomedical Engineering, Chemical Engineering, OR related discipline
- 1-3 years of lab experience
- Strong basic lab and data analysis skills
- Ability to learn new experimental methods
- Strong attention to detail
- Ability to conduct research
- Ability to manage multiple projects consecutively
- Demonstrated ability to bring structure to complex problems, pragmatic scoping and problem-solving approach, ability to objectively evaluate options/trade-offs and develop executive management-level recommendations

**What You Can Expect of Us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The base pay range for this opportunity in the U.S. is $28.87 per hour.

- Build a network of colleagues that will endure and grow throughout your time with us and beyond.
- Bring your authentic self to the table and become the professional youre inspired to be through accepting a culture that values the diversity of thought and experience and will flex to your strengths and possibilities.
- Participate in executive and social networking events, as well as community volunteer projects.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com** Please search for Keyword R-254516

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Candidates must be authorized to work in the U.S. for the duration of this program. Sponsorship for future FTE roles is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Senior Human Factors Engineer

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Senior Human Factors Engineer**

**What you will do**

Lets do this! Lets change the world! In this vital role you are responsible for leading HFE/UE planning, research, development, and continuous improvement of Amgen drug delivery devices using HFE/UE best practices and in accordance with current regulations and guidelines within the medical device, combination product and bio-pharmaceutical industries. The Senior Human Factors / Usability Engineer is a thought leader and user advocate both within the HF groups and to external teams. You will be a key stakeholder and collaborate with internal and external partners and across functions within marketing, engineering, risk, quality, safety, manufacturing, and regulatory teams. Our function is to design and implement human factors research to drive innovative and intuitive products. You will lead project study design, methodology, data collection, root cause analysis to inform design.You will support human factors and usability engineering activities to ensure the product user interface design of Amgens products support safe and effective use.

**Role Responsibilities:**

The Sr. HFE/UE responsibilities include but are not limited to:

- Partner cross-functionally with engineering, operations, regulatory, risk, quality, clinical, drug product, digital health, commercial to ensure Amgen products are safe and effective for end users.
- Lead and support human factors and usability engineering activities to improve the design of products, specifically the device-user interface. This includes the device, packaging, labeling, and instructions for use.
- Develop, strategize, and implement a risk-prioritized, fit-for-purpose approach to HF activities.
- Ensure human-system capabilities and limitations are accurately reflected in the system requirements, and HFE/UE input is provided across functions to develop device design, packaging, labeling, and training requirements.
- Identify, lead, and support appropriate human factors and usability engineering activities to improve the design of device-user interfaces, including the device, packaging, labeling, and instructions for use to minimize the potential for use errors.
- Analyze objective and subjective data from usability studies to inform product design, identify and mitigate use-risk, and provide robust solutions.
- Lead the design and execution of human factors formative and summative activities, including moderation, note taking, vendor engagement, and analysis of data.
- Support and provide HFE expertise in preparation for clinical studies and regulatory submissions in accordance with HF best practices, guidance and standards.
- Create documentation to support development activities, design controls, DHF, DMR including protocols, task analysis, use-related risk analysis (URRA), usability technical assessments, HF validation reports, and regulatory submissions.
- Clearly and actively communicate regularly with key internal and external partners.

This position may require up to 20% yearly travel mostly local and domestic.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The highly organized professional we seek is a problem solver and has the requisite training and experience to be an effective contributor and team members.

**Basic Qualifications:**

- Doctorate degree OR
- Master's degree and 2 years of Human Factors Engineering/Usability Engineering experience in the Biomedical/Pharmaceutical/Medical Device Field OR
- Bachelor's degree and 4 years of Human Factors Engineering/Usability Engineering experience in the Biomedical/Pharmaceutical/Medical Device Field OR
- Associate's degree and 8 years of Human Factors Engineering/Usability Engineering experience in the Biomedical/Pharmaceutical/Medical Device Field OR
- High school diploma/GED and 10 years of Human Factors Engineering/Usability Engineering experience in the Biomedical/Pharmaceutical/Medical Device Field

**Preferred Qualifications:**

- Bachelors or Master's degree in Human Factors, Usability Engineering, or other relevant Psychology, Industrial Design or Engineering discipline and 5-7 years of industry experience, working in multi-functional, fast-paced corporate environments.
- HF experience in the design and manufacturing of injectable devices (e.g., auto-injectors, pens, needle-free injectors, syringes) or devices for non-invasive/minimally invasive drug delivery systems (e.g., pulmonary, transdermal).
- HFE/UE experience planning, coordinating, conducting, analyzing, reporting human factors studies without vendor support.
- Experience with various HF methodologies such as ethnographic research, interviews, contextual inquiries, focus groups, technical assessments, device UI evaluation, knowledge and comprehension studies, HF professional analysis, task analysis, hazard analysis, risk assessment, formative and summative studies.
- Experience working directly with users to gather, synthesize and convert user research into concepts that differentiate products in the market, as well as to develop and evaluate new product features, user interfaces and ergonomic designs.
- Experience using low and high fidelity prototypes to identify and eliminate potential use errors early in the development process.
- Experience working in development organizations, particularly virtual development environments.
- Experience working within the development of systems design, verification, and validation.
- Functional knowledge and experience in the practical application of relevant FDA human factors guidance, regulations and standards, including IEC 62366, AAMI HE75, EN 60601-1-6, ISO 14971, MDR, and design controls.

**What you can expect from us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Principal Data Engineer

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

**Principal Data Engineer**

**What you will do**

Lets do this. Lets change the world. In this vital role you will lead the design, development, and implementation of our data strategy. The ideal candidatepossessesa deep understanding of data engineering principles, coupled with strong leadership and problem-solving skills. As a Principal Data Engineer, you will architect and oversee the development of robust data platforms, while mentoring and guiding a team of data engineers.

Roles & Responsibilities:

- Possesses strong rapid prototyping skills and can quickly translate concepts into working code.

- Provide expert guidance and mentorship to the data engineering team, fostering a culture of innovation and best practices.

- Design, develop, and implement robust data architectures and platforms to support businessobjectives.

- Oversee the development and optimization of datapipelines,and data integration solutions.

- Establish andmaintaindata governance policies and standards to ensure data quality, security, and compliance.

- Architect and manage cloud-based data solutions,leveragingAWS or other preferred platforms.

- Lead and motivate a high-performing data engineering team to deliver exceptional results.

- Identify, analyze, and resolve complex data-related challenges.

- Collaborate closely with business stakeholders to understand data requirements and translate them into technical solutions.

- Stay abreast of emerging data technologies and explore opportunities for innovation.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a **Principal Data Engineer** with these qualifications.

Functional Skills:

**Must-Have Skills:**

- Demonstratedproficiencyinleveragingcloud platforms (AWS, Azure, GCP) for data engineering solutions. Strong understanding of cloud architecture principles and cost optimization strategies.

- ProficientonexperienceinPython,PySpark,SQL.Handon experience withbiddataETL performance tuning.

- Proven ability to lead and develop high-performing data engineering teams.

- Strong problem-solving, analytical, and critical thinking skills to address complex data challenges.

**Good-to-Have Skills:**

- Experiencedwith data modeling and performance tuning for both OLAP and OLTP databases

- Experiencedwith Apache Spark, Apache Airflow

- Experiencedwith software engineering best-practices, including but not limited to version control (Git, Subversion, etc.), CI/CD (Jenkins, Maven etc.), automated unit testing, and Dev Ops

- Experiencedwith AWS, GCP or Azure cloud services

Education andProfessional Certifications

Doctorate degree and 2 years of**Data Engineer** experience

OR

Masters degree and 4 years of **Data Engineer** experience

OR

Bachelors degree and 6 years of**Data Engineer** experience

OR

Associates degree and 10 years of **Data Engineer** experience

OR

High school diploma / GED and 12 years of **Data Engineer** experience

- AWS Certified Data Engineerpreferred

- DatabricksCertificate preferred

Soft Skills:

- Excellent analytical and troubleshooting skills.

- Strong verbal and written communication skills

- Ability to work effectively with global, virtual teams

- High degree of initiative and self-motivation.

- Ability to manage multiple priorities successfully.

- Team-oriented, with a focus on achieving team goals

- Strong presentation and public speaking skills.

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Senior Manufacturing Systems Engineer: Automation PLC

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Be part of Amgen's newest and most advanced drug substance manufacturing plant. When completed, the Amgen FleX batch facility will combine the latest in disposable technologies with traditional stainless steel equipment to allow for maximum flexibility in operations The FleX Batch facility will not only feature the best in-class drug substance manufacturing technologies with embedded industry 4.0 capabilities, but it will also integrate sustainability innovations to reduce carbon and waste, as part of Amgen's plan to be a carbon-neutral company by 2027.

**Senior Manufacturing Systems Engineer: Automation PLC**

**What you will do**

Lets do this. Lets change the world. As a Senior Manufacturing Systems Engineer, you will provide automation technical leadership to a group of automation engineers who are responsible for building and maintaining various automation systems and platforms that support the GMP Drug Substance Plant Operations.

In this vital role as a member of the Facilities & Engineering (F&E) Automation team you will work hand in hand with the capital project team to deliver robust automation systems to operate the new plant utility and standalone systems. This includes complex and challenging system automation initiatives that require strong understanding of various automation platforms, integration between different platforms, analytical problem-solving techniques, project management, lifecycle management and Operational Excellence.

- Develop and maintain automation solutions utilizing various PLC's such as Allen Bradley, Siemens, etc. and integration with the Emerson DeltaV system.
- Develop and maintain Supervisory Control and Data Acquisition system (SCADA), Trailblazer reporting system, and equipment PLCs and interface hardware.
- Lead and support standalone system implementation and start-up, participate and provide technical guidance in the control panel / Human Machine Interfaces (HMI) layout and design including power distribution, grounding requirements, I/O assignments, etc.
- Work with process subject matter experts (SMEs) to understand key process requirements and transform them into digital automated solutions.
- Lead in continuous improvement and innovation initiatives for efficient operation and sustainability improvements of standalone systems.
- Collaborate with business partners to understand how standalone systems can improve workflow and productivity. Synthesize requirements from clients, customers, or end-users to develop the best automation solutions.
- Provide clear documentation for delivered solutions and processes; work closely with QA partners while supporting computerized systems validation processes in a GxP environment. Maintain Data Integrity Assessments with the current Amgen and Industry standards.
- Build the business processes to support the project scope in alignment with project timelines. Develop detailed specification and engineering policies and procedures that affect multiple organizational units.

**Ongoing operations:**

- Lead and support functional area projects focused on improving process equipment/utilities/facilities as well as large/sophisticated capital projects to integrate new drug substance manufacturing technologies into the facility.
- Lead and support technical root cause analysis, incident investigations, and troubleshooting on standalone systems.
- Lead and support new product introductions (NPI) or new technology introductions by performing automation engineering assessments, implementing automation system configuration changes and supporting engineering and process qualification runs as applicable.
- Lead Day-to-day Operational Support including: 24 x 7 Onsite/On Call Operational Support, Troubleshooting Support to Standalone Systems, Preventative and Corrective Maintenance, and Automation System spare parts management.
- Be constantly curious and feed your passion and interests in groundbreaking technology. Use your given time to look for new and innovative ways to do business differently, better, and more cost effectively.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The automation professional we seek is an engineer with these qualifications.

**Basic Qualifications:**

- High School Diploma / GED and 10 years of Engineering experience OR
- Associates Degree and 8 years of Engineering experience OR
- Bachelors Degree and 4 years of Engineering experience OR
- Masters Degree and 2 years of Engineering experience OR
- Doctorate Degree

**Preferred Qualifications:**

- Degree in Electrical Engineering or Computer Science, Chemical Engineering, or Biotech Engineering.
- Direct knowledge of PLC design, experience in controls engineering and troubleshooting with GMP biopharmaceutical production facility and utility equipment/systems automation such as autoclaves, parts washers, clean steam generator, WFI pretreatment RO, WFI stills, filter integrity testers, wastewater treatment systems, and integrating various OEM automation software.
- Extensive understanding and background in programming, design, installation, and lifecycle management of standalone controls, PLC, and field device/instrumentation technologies.
- Experience with Rockwell industrial automation hardware and systems, ability to perform sophisticated troubleshooting activities, System Integration using OPC, Foundation Fieldbus, Profibus, and DeviceNet technologies.
- Ability to interpret and apply GAMPs and GMPs and familiarity with documentation in a highly regulated environment with requirements such as 21 CFR Part 11, ASTM 2500, S88, and S95.
- Experience in Capital Project Lifecycle Management: Conceptual Design, Scope and cost estimate development, business case development, detailed design, engineering and validation documentation and project execution.
- Hands-on experience in developing process control strategies for New Product Introduction and New Technology Deployment for Drug Substance Plant Operations.
- Experience with continuous improvements resulting in enhanced safety, system reliability, and productivity (e.g., cycle times, and reduced plant utilities usage etc.) related to Drug Substance Plant Operations.
- The ideal individual must be a self-directed team player ready to mentor and develop engineering staff and embrace a team-based culture that relies on collaboration for effective decision-making.
- Strong leadership, technical writing, and communication/presentation skills.

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

**Apply now and make a lasting impact with the Amgen team!**

**careers.amgen.com**

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Machine Learning Engineer, AI Studio

**Join Amgens Mission of Serving Patients**

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Machine Learning Engineer, AI Studio

**What you will do**

The Machine Learning Engineer offers a unique opportunity to join a fun, innovative engineering team within the AI & Data Science (AI&D)- organization. We are the Applied AI team (AI Studio). AI Studio is Amgens enterprise engine for turning high-value business challenges into scalable AI products. We partner with key business partners across the company to identify the right opportunities, shape them into actionable use cases, and design, build, and launch AI products responsibly. Our work spans the full lifecycle from early discovery and rapid prototyping to production deployment, reuse across the enterprise, and measurable business impact. You will independently own defined production components within enterprise AI products and automation solutions.

Your remit may include a model or inference service, data or knowledge pipeline, retrieval component, agent tool, evaluation module, API, workflow or monitoring capability. You will design, release, diagnose and support the component while connecting technical measures to user and workflow outcomes. Within Applied AI, AI Studio turns prioritized business demand into governed, reusable AI assets with accountable ownership and measurable value across software, data, automation, machine learning, Generative AI, RAG, bounded agents, evaluation, observability and lifecycle operations.

**Key Responsibilities**

- Define component boundaries, intended use, acceptance criteria, non-functional requirements, decision consequences, support expectations and technical estimates with product and architecture partners.
- Design and implement maintainable Python, SQL, API, data, model, retrieval, agent-tool and workflow components with clear contracts, configuration, testing, error handling and documentation.
- Apply EDA, feature engineering, supervised or unsupervised methods, baselines, cross-validation, leakage prevention, calibration, subgroup, threshold, explainability and error analysis where relevant.
- Build GenAI, NLP, RAG and bounded agent components using structured output, embeddings, hybrid search, reranking, provenance, citations, permissions, approvals, retries and recoverable failure behaviour.
- Engineer batch or event-driven data, document, feature, embedding, label and evaluation pipelines with schema validation, lineage, provenance, access control and consistency checks.
- Define representative evaluation for model quality, uncertainty, retrieval, grounding, citations, task success, tool correctness, safety, latency, cost and user impact.
- Release and support components using cloud services, containers, CI/CD, versioning, monitoring, rollback, incident response and runbooks; lead diagnosis of moderately complex failures.
- Apply security, privacy, Responsible AI, validation, auditability, human oversight and applicable GxP controls; contribute reusable assets and guide Associate engineers on familiar work.

**What we expect of you**

We are all different, yet we all use our unique contributions to serve patients. The Machine Learning Engineer we seek is a professional with these qualifications.

**Basic Qualifications:**

Masters degree

OR

Bachelors degree and 2 years of Computer Science, IT or related field experience

OR

Associates degree and 6 years of Computer Science, IT or related field experience

OR

High school diploma / GED and 8 years of Computer Science, IT or related field experience

**Preferred Qualifications:**

- Production software and AI/ML system design: Python and SQL modules, APIs, background jobs, event flows, testing, performance, observability, source control and maintainable failure semantics.
- Statistics, modelling and experimentation: EDA, feature engineering, classification, regression, clustering, ensembles, cross-validation, leakage prevention, calibration, uncertainty and decision-aware error analysis.
- GenAI, RAG, knowledge and agents: Prompt and context management, structured output, chunking, embeddings, hybrid retrieval, reranking, citations, access-aware retrieval, tool schemas and human approval.
- Data, knowledge and cloud-scale systems: Batch and event-driven pipelines, contracts, lineage, provenance, relational/document/graph/vector stores, APIs, containers, Spark or Databricks and cloud-native services.
- Strong hands-on proficiency in Python and SQL, with sound software-engineering and testing practices.
- Strong capability in at least one of classical ML, GenAI/RAG/agents or MLOps/platform engineering, with working knowledge of adjacent areas.
- Advanced ML and deep learning: Experience with PyTorch, TensorFlow, Hugging Face, scikit-learn, XGBoost, PyMC, computer vision, NLP, GNNs, causal inference or uncertainty estimation.
- Advanced GenAI and knowledge systems: Experience with LangChain, LangGraph, LlamaIndex, Semantic Kernel, AutoGen, CrewAI, hybrid retrieval, knowledge graphs, graph RAG or evidence verification.
- Cloud, data and MLOps: Experience with AWS, Bedrock or SageMaker, Databricks, Spark, Kubernetes, infrastructure as code, MLflow, Airflow, Kubeflow or GitHub Actions.
- Agents and human-AI workflows: Familiarity with MCP-style integration, agent tracing, adversarial testing, durable workflows, permissions, human review, BI or process automation.
- Regulated enterprise delivery: Experience in healthcare, life sciences, GxP, validated systems or another regulated or high-impact environment.
- Independent problem solving and sound component-level technical judgment.
- Clear communication of assumptions, evidence, trade-offs, risks and support implications.
- Strong collaboration with business SMEs, product, architecture, software, data, platform, evaluation and control partners.
- Ownership, reliability and disciplined follow-through from design through production support.
- Ability to guide junior engineers and learn new tools through evidence-based experimentation.

**What you can expect of us**

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

- A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
- A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
- Stock-based long-term incentives
- Award-winning time-off plans
- Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

**Apply now and make a lasting impact with the Amgen team.**

**careers.amgen.com**

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

**Application deadline**

Amgen anticipates accepting applications until August 31st, 2026; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

**Sponsorship**

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.